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Development of Novel PCR Assays To Detect Azole Resistance-Mediating Mutations of the Aspergillus fu

Pulmonary Zygomycosis in a Non-neutropenic Patient With Myelodysplastic Syndrome on Lenalidomide

Prognosis of acute respiratory distress syndrome in neutropenic cancer patients

Early ultrasonographic finding of septic thrombophlebitis is the main indicator of central venous ca

Systematic review and meta-analysis of the value of clinical features to exclude radiographic pneumo

Pharmacokinetics of Tulathromycin in Healthy and Neutropenic Mice Challenged Intranasally with Lipop

Effects of cepharanthine with or without Z-100 against leukopenia during radiation therapy for oral

Questioning the Role of a Neutropenic Diet following Hematopoetic Stem Cell Transplantation

A European survey relating to cancer therapy and neutropenic infections: Nurse and patient viewpoint

Multiple cutaneous neutropenic ulcers associated with azathioprine

Diagnostic value of routine chest radiography in febrile, neutropenic children for early detection o

Pandemic 2009 influenza A(H1N1) virus infection coinciding with invasive pulmonary aspergillosis in

Comparative Pharmacodynamics of the New Oxazolidinone Tedizolid Phosphate and Linezolid in a Neutrop

Sudden Atelectasis and Respiratory Failure in a Neutropenic Patient: Atypical Presentation of Pseudo

ESCMID* guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult p

Can procalcitonin distinguish infectious fever from tumor-related fever in non-neutropenic cancer pa

Nasopharyngeal Detection of Respiratory Viruses in Febrile Neutropenic Children

Clinical utility and prognostic value of galactomannan in neutropenic patients with invasive aspergi

Diet of neutropenic patients in pediatric oncology service; the experience of the university hospita

Major surgery in a neutropenic patient undergoing allogeneic stem cell transplantation for high risk

應用抗甲狀腺藥物致粒細胞缺乏患者感染的臨床研究
作 者:任蕾,秦貴軍,鄭麗麗,張會娟,孫良閣,段宇

中華醫院感染學雜志 2014年第24卷第17期

【摘要】目的 分析使用抗甲狀腺藥物(ATD)引起粒細胞缺乏及引發感染患者的臨床特點和感染部位、病原菌分布及其耐藥性。 方法 回顧性分析72例使用ATD引起粒細胞缺乏及引發感染患者的臨床資料,采用SPSS11.0 軟件進行統計分析。 結果 72例患者感染部位以呼吸道為主,占55.3%,其次為泌尿系、胃腸道,分別占21.1% 和10.5%;共分離出病原菌52株,其中革蘭陽性菌20株占38.5%;革蘭陰性菌26株占50.0%;真菌6株占 11.5%;革蘭陽性菌對萬古霉素和替考拉寧敏感性最高,分別為90.0%和100.0%,對其他抗菌藥物均存在不同 程度的耐藥性;革蘭陰性菌對美羅培南和亞胺培南敏感性最高,均為92.3%,對第三代頭孢類藥物、阿米卡星等 存在不同程度的耐藥性。結論!使用 ATD容易引起患者粒細胞缺乏,繼而誘發各種感染,且感染部位以呼吸道 最為常見,引起感染的病菌中革蘭陰性菌與革蘭陽性菌相當,真菌感染相對較少。

【關鍵詞】抗甲狀腺藥物;粒細胞缺乏;感染

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